NeuroBiology & Genetics Group

"To educate and inspire through discoveries"

BOOKS / CHAPTERS

HC Lee, KL Tan, PS Cheah and KH Ling. JAK/STAT signalling pathway and gliosis in neuroinflammatory diseases. In: JAK-STAT Signaling in Diseases (Ed. Ritobrata Goswami). 1st Edition. Publisher: CRC Press, Boca Raton. pp 83-101. ISBN 9781351042468.

Yusoff K, Ling KH, Maniam J, Hairol MI, Loh HC, Teo WS and Samuel NK. A Nobel Trip to Lindau, Germany: Once in a Lifetime Opportunity. Publisher: Academy of Sciences Malaysia. pp.70. ISBN: 978-983-9445-85-5.

Cheah PS, Khin TZ, Che NMT, Fauziah O. 2012. Student’s Workbook for Medical Histology. First print. UPM Press. ISBN : 978-967-344-297-3.

Fauziah O, Cheah PS, Che Norma MT, Adam SK, Manan NA, Moklas MAM, San AA, Baharuldin MTH, Mahmud F. 2014. Eksplorasi Tubuh Manusia. ISBN : 978-967-344-378-9.

Cheah PS. (2016) Editorial. In: Nature’s Yield and Wonders of Art (NYAWA)16: Brain. University
Putra Malaysia, Serdang, Selangor, pp. 2-5. ISBN 9789679604153.

PEER-REVIEWED ARTICLES

2025

  1. Zainal Abidin S, Razali NN, Cheah PS, Ling KH. (2026). Biogenesis and Function of Circular RNAs and Their Implications in the Down Syndrome Brain. Frontiers in Genetics. 16, 1708015. https://doi.org/10.3389/fgene.2025.1708015
  2. Elbadie, M., Abdul Hamid, H., Ahmad, Z., & Ling, K.-H. (2025). Validated High-Resolution Melting Assays for Efficient Screening of DENND1A, LHCGR, FSHR, THADA, and CYP17A1 Polycystic Ovary Syndrome-Associated Gene Polymorphisms. Malaysian Journal of Medicine and Health Sciences, 21(6), 945.1 – 945.9. https://doi.org/10.47836/mjmhs.v21.i6.945
  3. Elbadie, M., Abdul Hamid, H., Ahmad, Z. and Ling, K. H. (2025). Phenotype-Specific Association of LHCGR rs13405728 Polymorphism with Anovulatory Infertility in Malay Women with PCOS: A Preliminary Report. (e731947). International Journal of Fertility and Sterility, (), e731947. https://doi.org/10.22074/ijfs.2025.2065767.1908
  4. CW Lim, H Abdul Hamid, KH Ling & PS Cheah. 2025. Oxidative stress in Down syndrome: unraveling the intertwined pathways for novel target identification. Current Opinion in Physiology, 46: 100864. https://doi.org/10.1016/j.cophys.2025.100864.
  5. I Mohammed Badamasi, MS Lye, N Ibrahim, NA Abdul Razaq, KH Ling & J Stanslas. 2025. Personality Trait and Antidepressant Type are Potential Moderators of the Association between Genotypes of HTR1A-rs6295 or HTR2A-rs6311 with Treatment Response. Clinical Schizophrenia & Related Psychoses, 19(1): 1-8.
  6. Pannirselvam S. C., Thambiah S., Appannah G., Ling K. H., Samsudin I. N., Hooper A. J., Yusoff M. R., Zakaria A. F., Razali R., Lau G. S. K., Zahari Sham S. Y., Lai Y. Y., Abdul Rahman T. H. and Zainal Abidin I. (2025) PUTRA-CV study protocol: a multicentre observational study of ethnic-specific genetic variants and dietary patterns in relation to lipoprotein(a) levels and their association with coronary artery disease severity in Malaysian adults. BMJ Open, 15, e103506. https://doi.org/10.1136/bmjopen-2025-103506
  7. Abdol Samat, H. N., Razali, N. N., Mahadzir, H., Tengku Muhammad, T. S., Ling, K.-H., Mansor, N. I., & Abidin, S. Z. (2025). The Interplay of Inflammation and Gut-Microbiota Dysbiosis in Alzheimer’s Disease: Mechanisms and Therapeutic Potential. International Journal of Molecular Sciences, 26(18), 8905. https://doi.org/10.3390/ijms26188905
  8. Chia, T.Y., Gan, CY., Cheah, PS. et al. (2025). Renoprotective and antihypertensive mechanism of action of Clinacanthus nutans bioactive polysaccharides by suppression of reactive oxygen species/ nuclear factor/ matrix metalloproteinase (ROS/NF-ΚB/MMP-9) and upregulation of  endothelial nitric oxide synthase/nitric oxide (eNOS/NO) pathways. Journal of Molecular Histology. 28;56(4):209 https://doi.org/10.1007/s10735-025-10481-9
  9. Abou HE, Prabhakar S, Cheah PS,  Hanlon KS, Espinoza P, Patel N, Cheng M, Hernández IV, Minderler S, de la Cruz D, Ng C, da Hora CC, Charest A, Stemmer-Rachamimov A, Jowett N, Breakefield XO, Maguire CA (2025). A comparative study of transduction of murine neurofibromas and sciatic nerve after systemic AAV administration. Gene Therapy. https://doi.org/10.1038/s41434-025-00542-9
  10. Abdullah, A. N., Fasihah Zamri, A., Alias, K., Azhar, N. M., Ling, K. H., Cheah, P. S., & Zainal Abidin, S. (2025). Transient prenatal ruxolitinib treatment promotes neurogenesis and suppresses astrogliogenesis during embryonic mouse brain development.Neuroscience Research Notes, 8(1), 352.1–352.7. https://doi.org/10.31117/neuroscirn.v8i1.352
  11. T Huang, S Fakurazi, PS Cheah, KH Ling. (2025). Dysregulation of REST and its target genes impacts the fate of neural progenitor cells in down syndrome. Scientific Reports, 15, 2818. https://doi.org/10.1038/s41598-025-87314-y.
  12. Lam XJ, Maniam S,  KH Ling & PS Cheah. (2025). Lithium restores nuclear REST and Mitigates oxidative stress in down syndrome iPSC-Derived neurons. Neuroscience, 567, 86-95. https://doi.org/10.1016/j.neuroscience.2024.12.061
  13. R Heidarzadehpilehrood, M Pirhoushiaran, MB Osman, KH Ling, H Abdul Hamid. 2025. A high-throughput RNA sequencing of peripheral blood mononuclear cells reveals an inflammatory state in women with PCOS. Archives of Medical Research, 56(3), 103129. https://doi.org/10.1016/j.arcmed.2024.10312
  14. Tomeh, A; Yusof Khan, AHK; Abu Zaid, Z; Ling, KH; Inche Mat, LN; Basri, H; Md Pauzi, AL; Romli, MH; Wan Sulaiman, WA. 2025. On the rising potential of interdisciplinary rehabilitation in neurological disorders: A mini-review. Medicine, 104(12): e41947. https://doi.org/10.1097/MD.0000000000041947
  15. A Tomeh, AHK Yusof Khan, Z Abu Zaid, KH Ling, LN Inche Mat, H Basri, WA Wan Sulaiman. 2025. Height-dependent variation in corticospinal excitability modulation after active but not sham intermittent theta burst stimulation. IBRO Neuroscience Reports, 18: 498-511. https://doi.org/10.1016/j.ibneur.2025.03.005
  16. H. Mohammed, M. ShikhMaidin, C.S.Y. Yong, K. H. Ling, & G.B. Martin. 2025. Expression of Progesterone Receptor Membrane Component 1 (PGRMC1) in Follicular and Luteal Tissues in Goats – Effect of Short-term Concentrate Supplementation. Tropical Animal Science Journal, 48(2):113-119. https://doi.org/10.5398/tasj.2025.48.2.113

2024

  1. T Huang, XJ Lam, CT Lim, N Jusoh, S Fakurazi, PS Cheah, KH Ling. 2024. Understanding perspectives and research trends in Down syndrome neuropathogenesis: A bibliometric analysis. Journal of Intellectual Disabilities, 17446295241299160. https://doi.org/10.1177/17446295241299160
  2. Shamsul Kamal, A. A., Fakiruddin, K. S., Bobbo, K. A., Ling, K. H., Vidyadaran, S., & Abdullah, S. (2024). Engineered Mesenchymal Stem Cells as Treatment for Cancers: Opportunities, Clinical Applications and Challenges. The Malaysian Journal of Medical Sciences, 31(5), 56–82. https://doi.org/10.21315/mjms2024.31.5.5
  3. M Azimzadeh, PS Cheah, KH Ling. Brain Insulin Resistance in Down Syndrome: Involvement of PI3K-Akt/mTor Axis in Early-Onset of Alzheimer’s Disease and Its Potential as A Therapeutic Target. Biochemical and Biophysical Research Communications, 2024, 150713. https://doi.org/10.1016/j.bbrc.2024.150713
  4. T Huang, S Fakurazi, PS Cheah, KH Ling. (2024) Chromosomal and cellular therapeutic approaches for Down syndrome: a research update. Biochemical and Biophysical Research Communications, 150664. https://doi.org/10.1016/j.bbrc.2024.150664.
  5. Lim CW, Hamakana G, Liang AC, Chan SJ, Ling KH, Lo Eng, Ken A, Cheah PS. (2024). In vitro Cytotoxicity Assessment of Ruxolitinib on Oligodendrocyte Precursor Cell and Neural Stem/Progenitor Cell Populations. NeuroToxicology, 105(2024): 10-20.  https://doi.org/10.1016/j.neuro.2024.08.004
  6. CY Fish-Low, LTL Than, KH Ling, Z Sekawi. (2024) The Potential of Eight Plasma Proteins as Biomarkers in Redefining Leptospirosis Diagnosis. Journal of Proteome Research, 23 (9), 4027-404. https://doi.org/10.1021/acs.jproteome.4c00376
  7. S Aissvarya, KH Ling, M Arumugam, K Thilakavathy. (2024) Molecular genetics of Dupuytren’s contracture. EFORT Open Reviews, 9 (8), 723-732.
  8. Azimzadeh M, Mohd Amirul Najwa Mohd Azmi, Reisi P, Cheah PS and Ling KH (2024). Step-by-step approach: Stereotaxic surgery for in vivo extracellular field potential recording at the rat Schaffer collateral-CA1 synapse using the eLab system. MethodsX. 102544. https://doi.org/10.1016/j.mex.2023.102544
  9. Azimzadeh M, Lim S.E., Mazhar NS, Ling KH and Cheah PS (2024). Prenatal ruxolitinib treatment improved muscle strength but showed no impact on the neurobehavioral and electrophysiological traits in adult mice. Neurochemical Journal. 18 (3): 483-491. https://doi.org/10.1134/S1819712424700168
  10. Lim CT, Lam XJ, Crystal AA, Huang T, Norhazlin J, Cheah PS and Ling KH (2024). Reduced REST expression in neural progenitor cells, adult cortex, and impaired REST nuclear translocation in the prefrontal cortex of Ts1Cje mouse model of Down syndrome. Neurochemical Journal. 18 (1):146-152. https://doi.org/10.1134/S1819712424010148
  11. Arumugam A, Nagalingam H, Jessie H, Cheah PS, Abdelwahab EMN. A cadaveric study of anatomical variation of sphenoparietal sinus & superficial sylvian draining veins. Gazzetta Medica Italiana – Arch Sci Med, 2024;183(5):429-437. https://doi.org/10.23736/S0393-3660.23.05224-5
  12. Lee YL, Ting TH, Lim CT, Thilakavathy K, Musa NH, Ling KH. (2024) Identification of a Novel IGSF1 Variant in Two Malaysian Male Siblings with Central Hypothyroidism and Macroorchidism. Journal of Clinical Research in Pediatric Endocrinology.  https://doi.org/10.4274/jcrpe.galenos.2024.2023-12-1
  13. SS Lee, KH Ling, R Subramaniam, M Tusimin, KF Rahim, SP Loh. (2024) Genetic variants and non-genetic factors associated with a high prevalence of vitamin D deficiency in full-term neonates in Malaysia. Human Nutrition & Metabolism, 36, 200259.  https://doi.org/10.1016/j.hnm.2024.200259.
  14. Meyer K, Ling KH, Yeo PL, Spathopoulou A, Drake D, Choi J, Aron L, Garcia-Corral M, Ko T, Lee E, Tam J, Perlis R, Church G, Tsai LH & Yankner B. (2024). Impaired neural stress resistance and loss of REST in bipolar disorder. Molecular Psychiatry. 29:153-164. https://doi.org/10.1038/s41380-023-02313-7

2023

  1. Arumugam A, Nagalingam H, Jessie H, Cheah PS, Abdelwahab EMN. A cadaveric study of anatomical variation of sphenoparietal sinus & superficial sylvian draining veins. Gazzetta Medica Italiana – Arch Sci Med, 2023;182:000-000. https://doi.org/10.23736/S0393-3660.23.05224-5
  2. Hassan Z., Singh D., Suhaimi F.W., Chear N.J.Y., Harun N., Cheah PS, Singh G.K.G, Mat N.H., Syuhadaa Bakar S.M., Mohd. Yusof N.B., Kasinather V.B., Chawarski M.C., Murugaiyah V., Ramanathan S. Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats. Regulatory Toxicology and Pharmacology. 2023;143:105466. https://doi.org/10.1016/j.yrtph.2023.10546
  3. Mustapha M., Bhanu Prakash K.N., Cheah PS, Feng L. New Challenges and Future Perspectives in Pathological Conditions. Frontiers in Behavioral Neuroscience (Editorial). 2023; 17:1201044 https://doi.org/10.3389/fnbeh.2023.1201044
  4. Huang T, Fakurazi S, Cheah P-S, Ling K-H. REST Targets JAK–STAT and HIF-1 Signaling Pathways in Human Down Syndrome Brain and Neural Cells. International Journal of Molecular Sciences. 2023; 24(12):9980. https://doi.org/10.3390/ijms24129980
  5. Lee, Yee-Lin, Ting, Tzer-Hwu, Lim, Chong-Teik, Arrumugam-Arthini, Crystal, Karuppiah, Thilakavathy and Ling, King-Hwa. “Novel PAX4 variant in a child and family with diabetes mellitus – case report and review of the literature” Journal of Pediatric Endocrinology and Metabolism, 2023. https://doi.org/10.1515/jpem-2023-01
  6. Lam XJ, Maniam S, Cheah PS, Ling KH. REST in the Road Map of Brain Development. Cellular and Molecular Neurobiology. 2023 Jul 30. https://doi.org/10.1007/s10571-023-01394-w Epub ahead of print. PMID: 37517069.
  7. Mansor, N. I., Ling, K. H., Rosli, R., Hassan, Z., Adenan, M. I., & Nordin, N. (2023). Centella asiatica (L.) Urban. Attenuates Cell Damage in Hydrogen Peroxide-Induced Oxidative Stress in Transgenic Murine Embryonic Stem Cell Line-Derived Neural-Like Cells: A Preliminary Study for Potential Treatment of Alzheimer’s Disease. Journal of Alzheimer’s disease: JAD, 94(s1): S21-S44. Advance online publication. https://doi.org/10.3233/JAD-221233
  8. Zhou, Q., Tian, L., Jia, X., Ling, K. H., Mohd Nor, N. H., Harun, M. H., Feng, D., & Wan Sulaiman, W. A. (2023). Extract from the paralyzed spinal cord of rats enhances neural stem cell proliferation in the neonatal rat brain by upregulating the Notch1/Hes1 pathway. Minerva Pediatrics, 10.23736/S2724-5276.23.07322-6. Advance online publication. https://doi.org/10.23736/S2724-5276.23.07322-6
  9. XJ Lam, B Xu, PL Yeo, PS Cheah, KH Ling. Mitochondria dysfunction and bipolar disorder: From pathology to therapy. IBRO Neuroscience Reports, 2023; 14: 407-418. https://doi.org/10.1016/j.ibneur.2023.04.002.
  10. Mot YY, Moses EJ, Mohd Yusoff N, Ling KH, Yong YK, Tan JJ. 2023. Mesenchymal Stromal Cells-Derived Exosome and the Roles in the Treatment of Traumatic Brain Injury. Cellular and Molecular Neurobiology, 43, 469–489. https://doi.org/10.1007/s10571-022-01201-y.
  11. KL Tan, HC Lee, PS Cheah & KH Ling. 2023. Mitochondrial Dysfunction in Down Syndrome: From Pathology to Therapy. Neuroscience, 511, 1-12. https://doi.org/10.1016/j.neuroscience.2022.12.003.
  12. N Azmi, SS Mustaffa Al Bakri, W Khor, SN Hamzah, N Ferdaos, KH Ling, N Nordin. Neural fate commitment of rat full-term amniotic fluid stem cells via three-dimensional embryoid bodies and neurospheres formation, IBRO Neuroscience Reports, 2023, 14: 235-243. https://doi.org/10.1016/j.ibneur.2023.01.003
  13. Heidarzadehpilehrood, M Pirhoushiaran, M Osman, H Abdul Hamid, KH Ling. Weighted Gene Co-Expression Network Analysis (WGCNA) Discovered Novel Long Non-Coding RNAs for Polycystic Ovary Syndrome. Biomedicines, 2023 Feb 10;11(2):518. doi:10.3390/biomedicines11020518

2022

  1. KH Ling & PS Cheah. 2022. The Struggle of Neural Progenitors in Down Syndrome Brain: The Need for Neuromodulation Beyond Symptomatic Mitigations. Malaysian Journal of Medicine and Health Sciences, 18(6); 1-4. doi: https://doi.org/10.47836/mjmhs18.5.1
  2. Ahmadloo, S., Ling, KH., Fazli, A. et al. Signature pattern of gene expression and signaling pathway in premature diabetic patients uncover their correlation to early age coronary heart disease. Diabetology Metabolic Syndrome, 14, 107 (2022). https://doi.org/10.1186/s13098-022-00878-x
  3. Prabhakar S, Beauchamp RL, Cheah PS, Yoshinaga A, Haidar EA, Lule S, Mani G, Maalouf K, Stemmer-Rachamimov A, Jung DH, Welling DB, Giovannini M, Plotkin SR, Maguire CA, Ramesh V, Breakefield XO. 2022. Gene replacement therapy in a schwannoma mouse model of neurofibromatosis type 2. Molecular Therapy – Methods & Clinical Development. 26:169-180. https://doi.org/10.1016/j.omtm.2022.06.012
  4. Aldoghachi A.F., Aldoghachi A.F., Breyne K., Ling K.H., Cheah P.S. 2022. Recent Advances in the Therapeutic Strategies of Glioblastoma Multiforme. Neuroscience, 491, 240-270. https://doi.org/10.1016/j.neuroscience.2022.03.030.
  5. L. Nieland, T.S. van Solinge, P.S. Cheah, L.M. Morsett, J. El Khoury, J. I. Rissman, Benjamin P. Kleinstiver, Marike L.D. Broekman, Xandra O. Breakefield, Erik R. Abels, 2022. CRISPR-Cas knockout of miR21 reduces glioma growth. Molecular Therapy – Oncolytics, 25, 121-136. https://doi.org/10.1016/j.omto.2022.04.001 
  6. Mohadese Hashem Boroojerdi, Vahid Hosseinpour Sarmadi, Maryam Maqbool, King-Hwa Ling, Pooria Safarzadeh Kozani, Pouya Safarzadeh Kozani, Rajesh Ramasamy. Directional capacity of human mesenchymal stem cells to support hematopoietic stem cell proliferation in vitro. Gene, 2022, 820: 146218. https://doi.org/10.1016/j.omto.2022.04.001
  7. Lee, Siew S., King H. Ling, Maiza Tusimin, Raman Subramaniam, Kartini F. Rahim, and Su P. Loh. 2022. “Interplay between Maternal and Neonatal Vitamin D Deficiency and Vitamin-D-Related Gene Polymorphism with Neonatal Birth Anthropometry” Nutrients 14, no. 3: 564. https://doi.org/10.3390/nu14030564

2021

  1. Tan J.J., Guyette J.P., Miki K., Xiao L., Kaur G., Wu T., Zhu L., Hanse K., Ling K.H., Milan D.J. and Ott H.C. (2021) Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro. Nature Communications, 12(4997):1-19. https://doi.org/10.1038/s41467-021-24921-z
  2. Prabhakar S, Lule S, Da Hora CC, Breakefield XO, Cheah PS. (2021). AAV9 transduction mediated by systemic delivery of vector via retro-orbital injection in newborn, neonatal and juvenile mice. Experimental Animals. Article ID: 20-0186. https://doi.org/10.1538/expanim.20-0186
  3. Lye, M.-S., Tor, Y.-S., Tey, Y.-Y., Shahabudin, A., Loh, S.-P., Ibrahim, N., Stanslas, J., Rosli, R., & Ling, K.-H. (2021). BsmI-ApaI-TaqI TAC (BAt) Haplotype of Vitamin D Receptor Gene Is Associated with Increased Risk of Major Depressive Disorder. Journal of Molecular Neuroscience. 71 (5), 981-990. https://doi.org/10.1007/s12031-020-01719-0
  4. IM Badamasi, MS Lye, N Ibrahim, KH Ling & J Stanslas. Serotonergic receptor gene polymorphism and response to selective serotonin reuptake inhibitors in ethnic Malay patients with first episode of major depressive disorder. Pharmacogenomics Journal (2021). https://doi.org/10.1038/s41397-021-00228-6
  5. Zainal Abidin, S., Lee, H.-C., Abdullah, S., Nordin, N., Cheah, P.-S. and Ling, K.-H. (2021) “The expression profile of miR-3099 during neural development of Ts1Cje mouse model of Down syndrome”, Neuroscience Research Notes, 4(1), pp. 7–15.
  6. S Liu, S Punthambaker, EPR Iyer, T Ferrante, D Goodwin, D Furth, AC Pawlowski, K Jindal, JM Tam, L Mifflin, S Alon, A Sinha, AT Wassie, F Chen, A Cheng, V Willocq, K Meyer, KH Ling, C Camplisson, A Skrynnyk, RE Kohman, J Aach, J Lee, BA Yankner, ES Boyden & GM Church. Barcoded oligonucleotides ligated on RNA amplified for multiplex and parallel in situ analyses. Nucleic Acids Research, 2021; gkab120
  7. HC Lee, H Hamzah, MPY Leong, H Md Yusof, O Habib, S Zainal Abidin, EA Seth, SM Lim, S Vidyadaran, MA Mohd Moklas, MA Abdullah, N Nordin, Z Hassan, PS Cheah & KH Ling. Transient prenatal ruxolitinib treatment suppresses astrogenesis during development and improves learning and memory in adult mice. Scientific Reports. 2021, 11, 3847 (2021). https://doi.org/10.1038/s41598-021-83222-z
  8. Cheah P.S., Prabhakar S., Yellen D., Beauchamp R. L., Zhang X., Kasamatsu S., Bronson R. T., Thiele E. A., Kwiatkowski D. J., Stemmer-Rachamimov A., Gyorgy B., Ling K.-H., Kaneki M., Tannous B. A., Ramesh, V., Maguire C.A., Breakefield X. O. Gene therapy for tuberous sclerosis complex type 2 in a mouse model by delivery of AAV9 encoding a condensed form of tuberin. Science Advances, 2021; 7(2): eabb1703. doi: 10.1126/sciadv.abb1703
  9. Al Ali J, Vaine CA, Shah S, Campion L, Hakoum A, Supnet ML, Acuña P, Aldykiewicz G, Multhaupt-Buell T, Ganza NGM, Lagarde JBB, De Guzman JK, Go C, Currall B, Trombetta B, Webb PK, Talkowski M, Arnold SE, Cheah PS, Ito N, Sharma N, Bragg DC, Ozelius L, Breakefield XO. TAF1 Transcripts and Neurofilament Light Chain as Biomarkers for X-Linked Dystonia-Parkinsonism. Movement Disorders.
    2021 Jan;36(1):206-215. doi: 10.1002/mds.28305. Epub 2020 Sep 25.
  10. Mansor NI, Ntimi CM, Abdul-Aziz NM, Ling KH, Adam A, Rosli R, Hassan Z, Nordin N. Asymptomatic neurotoxicity of amyloid β-peptides (aβ1-42 and aβ25-35) on mouse embryonic stem cell-derived neural cells. Bosnian Journal of Basic Medical Sciences, 2021; 21(1): 98–110. https://doi.org/10.17305/bjbms.2020.4639

2020

  1. Jouha Min, Taehwang Son, Jae-Sang Hong, Cheah PS, Andreas Wegemann, Xandra O. Breakefield, Ralph Weissleder, Hakho Lee, Hyungsoon Im. Plasmon-enhanced biosensing for multiplexed profiling of extracellular vesicles. Advanced Biosystem,
    2020 Dec; 4(12):e2000003. doi: 10.1002/adbi.202000003. Epub 2020 Aug 19.
  2. O Habib, R Mohd. Sakri, N Ghazalli, DM Chau, KH Ling, S Abdullah. Limited expression of non-integrating CpG-free plasmid is associated with increased nucleosome enrichment. PLoS ONE, 2020 Dec 21;15(12):e0244386. doi: 10.1371/journal.pone.0244386.
  3. Lee, SS., Ling, KH., Tusimin, M., Subramaniam, R., Rahim, KF., Loh, SP. Influence of vitamin D binding protein polymorphism, demographics and lifestyle factors on vitamin D status of healthy Malaysian pregnant women. BMC Pregnancy Childbirth, 20, 714 (2020). https://doi.org/10.1186/s12884-020-03397-7
  4. Lee SS, Subramaniam R, Tusimin M, Ling KH, Rahim KF, Loh SP.   Inadequate vitamin D intake among pregnant women in Malaysia based on revised recommended nutrient intakes value and potential dietary strategies to tackle the inadequacy. Nutr Res Pract. 2020;14:e77
  5. Seth EA, Lee HC, Yusof HH, Nordin Norshariza, Cheah YK, Ho ETW, Ling KH, Cheah PS. (2020) Phenotype microarrays reveal metabolic dysregulations of neurospheres derived from embryonic Ts1Cje mouse model of Down syndrome. PLoS One. 15(7): e0236826.  https://doi.org/10.1371/journal.pone.0236826 
  6. Cheah, P.-S., Ling, K.-H. and Ho, E. T. W. (2020) From online resources to collaborative global neuroscience research: where are we heading?, Neuroscience Research Notes, 3(3): 1-8. doi: 10.31117/neuroscirn.v3i3.51
  7. Faris, A., Cheah, P.-S. and Ling, K.-H. Single nucleotide polymorphism of BDNF Val66Met (rs6265) and its association to neuropsychiatric disorders, Neuroscience Research Notes, 2020; 3(3): 9-26. doi: 10.31117/neuroscirn.v3i3.50.
  8. Damodaran T, Cheah PS, Murugaiyah V., Hassan Z. The nootropic and anticholinesterase activities of Clitoria ternatea Linn. root extract : potential treatment for cognitive decline. Neurochemistry International, 2020; 139: 104785. https://doi.org/10.1016/j.neuint.2020.104785
  9. M Wang, KH Ling, JJ Tan, CB Lu. Development and Differentiation of Midbrain Dopaminergic Neuron: From Bench to Bedside. Cells, 2020; 9(6): 1489. https://doi.org/10.3390/cells9061489
  10. Srinivasan S, Treacy R, Herrero T, Olsen R, Leonardo TR, Zhang X, DeHoff P, To C, Poling LG, Fernando A, Leon-Garcia S, Knepper K, Tran V, Meads M, Tsarz J, Vuppala A, Park S, Laurent CD, Bui T, Cheah PS, Overcash R, Ramos GA, Roeder H, Ghiran I, Parast M, Breakefield XO, Lueth AJ, Rust SR, Dufford MT, Fox AC, Hickok DE, Burchard J, Boniface JJ. Laurent LC,. Discovery and verification of extracellular miRNA biomarkers for non-invasive prediction of preeclampsia in asymptomatic women. Cell Reports Medicine. 2020, 1(2): 100013.
  11. Lucero R, Zappulli V, Sammarco A, Murillo OD, Cheah PS, Srinivasan S, Tai E, Ting DT, Wei ZY, Roth ME, Laurent LC, Krichevsky AM, Breakefield XO, Milosavljevic A. Glioma-derived miRNA-containing extracellular vesicles induce angiogenesis by reprogramming brain endothelial cells. Cell Reports. 2020, 30: 2065-2074.
  12. R Hassan, Cheah PS, S Sreenivasan, SM Mansor, CP Muller and Z Hassan. Mitragynine attenuates morphine withdrawal effects in rats – a comparison with methadone and buprenorphine. Frontiers in Psychiatry. 2020; 11: 411. doi: 10.3389/fpsyt.2020.00411
  13. Cruz L, György B, Cheah PS, Kleinstiver BP, Eimer WA, Aufiero M, Garcia SP, Sharma N, Ozelius LJ, Bragg DC, Joung JK, de Souza ON, Timmers LFSN, Breakefield XO. Mutant allele-specific CRISPR disruption in DYT1 dystonia fibroblasts restores cell function. Molecular Therapy – Nucleic Acids. 2020, 21:1-12.
  14. Lye M-S, Tey Y-Y, Tor Y-S, Shahabudin AF, Ibrahim N, Ling K-H, Stanslas J, Loh S-P, Rosli R, Lokman KS, Mohammed Badamasi I, Aldoghachi AF, Nurul AF, Abdul Razak A. Predictors of recurrence of major depressive disorder. PLoS ONE. 2020; 15(3): e0230363. https://doi.org/10.1371/journal.pone.0230363
  15. PJ Kaboli and KH Ling. Lapatinib as a Dual Tyrosine Kinase Inhibitor Unexpectedly Activates Akt in MDA-MB-231 Triple-Negative Breast Cancer Cells. Letters in Drug Design & Discovery. 2020; 17: 1. https://doi.org/10.2174/1570180817666200212125658.
  16. Sarmadi VH, Ahmadloo S, Boroojerdi MH, John CM, Al-Graitte SJR, Lawal H, Maqbool M, KH Ling, Ramasamy. Human Mesenchymal Stem Cells-mediated Transcriptomic Regulation of Leukemic Cells in Delivering Anti-tumorigenic Effects. Cell Transplantation. 2020 Jan-Dec;29:963689719885077. doi: 10.1177/0963689719885077.
  17. SS Lee, SP Loh, R Subramaniam, M Tusimin, KH Ling, KF Rahim. Association of Maternal and Cord Plasma Total, Free and Bioavailable 25-Hyrodroxyvitamin D with Neonatal Anthropometric Measurements at Birth: A Preliminary Study in a Private Hospital. Malaysian Journal of Medicine and Health Sciences. 2020; 16(1): 24-31.
  18. Fish-Low C-Y, Balami AD, Than LTL, Ling KH, Mohd Taib N, Shah AM, Sekawi Z. Hypocalcemia, hypochloremia, andeosinopenia as clinical predictors of leptospirosis: A retrospective study. Journal of Infection and Public Health. 2020; 13(2): 216-220, https://doi.org/10.1016/j.jiph.2019.07.021
  19. Fish-Low CY, Than LTL, Ling KH, Lin Q, Sekawi Z. Plasma proteome profiling reveals differentially expressed lipopolysaccharide-binding protein among leptospirosis patients. Journal of Microbiology, Immunology and Infection. 2020; 53(1):157-162. doi: 10.1016/j.jmii.2018.12.015.

2019

  1. NN Razali, TH Ting, KH Ling, M L Kennerson, K Thilakavathy. Predicting the Impact of PHEX, FGF23 and DMP1 Gene Variants Found in Malaysian Malay Patients with Hypophosphataemic Rickets Through In Silico Analysis of Protein Function and mRNA Secondary Structure. Journal of Biochemistry, Microbiology and Biotechnology. 2019; 7(2):14-23.
  2. S Jafarian, KH Ling, Z Hassan, L Perimal-Lewis, MR Sulaiman, EK Perimal. Effect of zerumbone on scopolamine-induced memory impairment and anxiety-like behaviours in rats. Alzheimer’s & Dementia: Translational Research & Clinical Interventions. 2019; (5): 637-643.
  3. NI Mansor, N Nordin, F Mohamed, KH Ling, R Rosli and Z Hassan. Crossing the Blood-Brain Barrier: A Review on Drug Delivery Strategies for Treatment of the Central Nervous System Diseases. Current Drug Delivery (2019) 16(8): 698-711. https://doi.org/10.2174/1567201816666190828153017
  4. MS Lye, AF Shahbudin, YY Tey, YS Tor, KH Ling, N Ibrahim, J Stanslas, SP Loh, R Rosli. Zinc Transporter-3 [SLC30A3 (rs11126936)] Polymorphism is associated with Major Depressive Disorder in Asian Subjects. Neuroscience Research Notes. 2019; 2(3): 20-28. https://doi.org/10.31117/neuroscirn.v2i3.34
  5. Z Hassan, FW Suhaimi, S Ramanathan, KH Ling, MA Effendy, CP Müller and HC Dringenberg. Mitragynine (Kratom) impairs spatial learning and hippocampal synaptic transmission in rats. Journal of Psychopharmacology. 2019; 33(7):908-918. https://doi.org/10.1177/0269881119844186
  6. Srinivasan S, Yeri A, Cheah PS, Chung A, Danielson K, De Hoff P, Filant J, Laurent CD, Laurent LD, Magee R, Moeller C, Murthy VL, Nejad P, Paul A, Rigoutsos I, Rodosthenous R, Shah RV, Simonson B, To C, Wong D, Yan IK, Zhang X, Balaj L, Breakefield XO, Daaboul G, Gandhi R, Lapidus J, Londin E, Patel T, Raffai RL, Sood AK, Alexander RP, Das S, Laurent LC. Small RNA Sequencing across Diverse Biofluids Identifies Optimal Methods for exRNA Isolation. Cell. 2019;177(2):446-462.e16. doi: 10.1016/j.cell.2019.03.024.
  7. Zaborowski MP, Cheah PS, Zhang X, Bushko I, Lee K, Sammarco A, Zappulli V, Maas SLN, Aleen RM, Rumde P, Gyorgy B, Aufiero M, Schweiger MW, Lai CP, Fulci G, Weissleder R, Lee H, Vickers KC, Tannous BA, Breakefield XO. Membrane-bound Gaussia luciferase as a tool to track shedding of membrane proteins from the surface of extracellular vesicles. Scientific Reports. 2019; 9: 17387. https://doi.org/10.1038/s41598-019-53554-y
  8. Prabhakar S, Cheah PS, Zhang X, Zinter M, Gianatasio M, Hudry E, Bronson RT, Kwiatkowski DJ, Stemmer-Rachamimov A, Maguire CA, Sena-Esteves M, Tannous B, Breakefield XO. Long-term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in mouse model of tuberous sclerosis type 1. Molecular Therapy-Methods and Clinical Development. 2019; 15: 18-26. https://doi.org/10.1016/j.omtm.2019.08.003
  9. Chan SJ, Niu WT, Hayakawa K, Hamanaka G, Wang XY, Cheah PS, Guo SZ, Yu ZY, Arai K, Selim M, Kurisawa M, Spector M, Lo E. Promoting neuro-supportive properties of astrocytes with epidermal growth factor hydrogels. Stem Cell Translational Medicine. 2019; 8: 1242-1248. http://dx.doi.org/10.1002/sctm.19-0159
  10. Abels ER, Maas SLN, Nieland L,Wei ZY, Cheah PS, Tai E, Kolsteeg CJ, Dusoswa S, Ting DT, Hickman S, Krichevsky AM, Khoury JE, Krichevsky AM, Broekman MLD, Breakefield XO. Extracellular transfer of miR-21 contributes to microglia reprogramming in intracranial glioma. Cell Reports. 2019; 28(12): 3105-3119. https://doi.org/10.1016/j.celrep.2019.08.036
  11. Lim CL, Bala U, Leong MPY, Ivan YKS, Stanslas J, Ramasamy R, Ling KH, Cheah PS. Perturbed metabolic profiles associated with muscle weakness seen in adult Ts1Cje mouse model of Down syndrome. Japanese Journal of Veterinary Research. 2018; 67(1): 111-118. (IF = 1.142)
  12. Pinkham K, Park DJ, Hashemiaghdam A, Kirov A, Adam I, Rosiak K, da Hora CC, Teng J, Cheah PS, Ganguli-Indra G, Kelly A, Indra AK, Badr CE. Stearoyl CoA Desaturase is essential for regulation of ER homeostasis and tumor growth in glioma stem-like cells. Stem Cell Reports. 2019; 12: 712-727. https://doi.org/10.1016/j.stemcr.2019.02.012
  13. Zaborowski MP, Lee K, Na YJ, Sammarco A, Zhang X, Iwanicki M, Cheah PS, Fulci G, Tannous BA, Lai CP, Birrer CP, Weissleder R, Lee H, Breakefield XO. Systematic identification of membrane proteins for specific capture of cancer-derived extracellular vesicles. Cell Reports. 2019; 27: 255-268. doi: 10.1016/j.celrep.2019.03.003.
  14. IA Aliyu, K-H Ling, NF Md Hashim, JY Lam, HY Chee. Annexin II as a Dengue Virus Serotype 2 Interacting Protein Mediating Virus Interaction on Vero Cells. Viruses. 2019; 11(4).pii: E335. doi: 10.3390/v11040335.
  15. K Meyer, HM Feldman, T Lu, D Drake, ET Lim, KH Ling, NA Bishop, Y Pan, J Seo, YT Lin, SC Su, GM Church, LH Tsai and BA Yankner. REST and Neural Gene Network Dysregulation in iPS Cell Models of Alzheimer’s Disease. Cell Reports. 2019; 26(5): P1112-1127.e9.
  16. Zainal Abidin S, Fam SZ, Chong CE, Abdullah S, Cheah PS, Nordin N, Ling KH. 2019. miR-3099 promotes neurogenesis and inhibits astrogliogenesis during murine neural development. Gene. 2019; 697: 201-212. doi: 10.1016/j.gene.2019.02.014
  17. Lee HC, Yusof HH, Leong MPY, Zainal Abidin S, Seth EA, Hewitt CA, Vidyadaran S, Nordin N, Scott HS, Cheah PS, Ling KH. 2019. Gene and protein expression profiles of JAK-STAT signalling pathway in the developing brain of the Ts1Cje Down syndrome mouse model. International Journal of Neuroscience. 2019; 129(9): 871-881. doi: 10.1080/00207454.2019.1580280
  18. Yusof HH, Lee HC, Seth EA, Wu XZ, Hewitt CA, Scott HS, Cheah PS, Li YM, Chau DM, Ling KH. Expression profiling of Notch signaling pathway and gamma secretase activity in the brain of Ts1Cje mouse model of Down syndrome. Journal of Molecular Neuroscience. 2019; 67(4):632-642. doi: 10.1007/s12031-019-01275-2
  19. Aldoghachi AF, Tor YS, Redzun SZ, Lokman KA, Razaq NAA, Shahbudin AF, Badamasi IM, Cheah PS, Stanslas J, Veerakumarasivam A, Rosli R, Ibrahim N, Lye MS, Ling KH. Screening of brain-derived neurotrophic factor (BDNF) single nucleotide polymorphisms and plasma BDNF levels among Malaysian major depressive disorder patients. Plos ONE. 2019; 14(1): e0211241. doi: 10.1371/journal.pone.0211241
  20. Aliyu IA, Ling K‐H, Md Hashim N, Chee H‐Y. Annexin A2 extracellular translocation and virus interaction: A potential target for antivirus‐drug discovery. Reviews in Medical Virology. 2019; 29(3): e2038. https://doi.org/10.1002/rmv.2038
  21. Jabbarzadeh Kaboli P, Leong MPY, Ismail P, Ling KH. Anti-tumor effects of Barberine against EGFR, ERK1/2, P38and AKT in MDA-MB231 and MCF-7 breast cancer cell using molecular modelling and in vitro study. Pharmacological Reports. 2019; 71(1): 13-23. https://doi.org/10.1016/j.pharep.2018.07.005
  22. Cheah PS, Mason J. and Ling KH. Challenges and future perspectives for 3D cerebral organoids as a model for complex brain disorders. Neuroscience Research Notes. 2019; 2(1): 1-6. doi: 10.31117/neuroscirn.v2i1.28.

2018

  1. Bala, U., Leong, M. P.Y., Lim, C. L., Shahar HK, Othman F, Lai, M.I., Ling, K.H, Cheah, P.S. Ultrastructural study of sciatic nerve in Ts1Cje mouse model for Down syndrome: an implication of peripheral nerve defects in hypotonia. Neuroscience Research Notes. 2018. 1(2): 1-9.
  2. Jaafar A, Alsiddiq F, Ling KH. Pathogenic mutations in ARX, CDKL5 and STXBP1 genes are not associated with the early-onset epileptic encephalopathy in Malaysian pediatric patients: A pilot study. Neuroscience Research Notes. 2018. 1(3): 5-17.
  3. Ling KH, Abdul-Aziz NM and Nordin N. Free open access to liberate and unleash neglected science. Neuroscience Research Notes. 2018; 1(1): 1-2. doi: 10.31117/neuroscirn.v1i1.4.
  4. Leong MPY, Bala U, Lim CL, Rosli R, Cheah PS and Ling KH. Transcriptomic profiling of skeletal muscles from the Ts1Cje mouse model of Down syndrome suggests dysregulation of trisomic genes associated with neuromuscular junction signaling, oxidative stress and chronic inflammation. Neuroscience Research Notes. 2018; 1(1): 21-41. doi:10.31117/neuroscirn.v1i1.12.
  5. Lim CL, Bala U, Leong MPY, Stanslas J, Ramasamy R, Ling KH and Cheah PS. Cellular function of satellite cells does not play a role in muscle weakness of adult Ts1Cje mice. Neuroscience Research Notes. 2018; 1(1): 3-10. doi: 10.31117/neuroscirn.v1i1.6.
  6. Lim CL, Ling KH, Cheah PS. Isolation, cultivation and immunostaining of single myofibers- an improved approach to study the behaviour of satellite cells. Journal of Biological Methods. 2018;5(1):e87. DOI: 10.14440/jbm.2018.2192018.
  7. Zainal Abidin S, Lee HC, Fam SZ, Abdullah S, Nordin N, Cheah PS, Ling KH. Construction and validation of a mammalian expression vector for in utero electroporation study of miR-3099 in the mouse neocortex. Malaysian Journal of Medicine and Health Sciences. 2018; 14(SP1): 20-29.
  8. Faris A, Yusof H, Zainal Abidin S, Habib O, Cheah PS, Stanslas J, Ibrahim N, Lye MS, Veerakumarasivam A, Rosli R, Ling KH. Development and validation of High Resolution Melting assays for high-throughput screening of BDNF rs6265 and DAT1 rs40184. Malaysian Journal of Medicine and Health Sciences. 2018; 14(SP1): 64-71.
  9. Volak A, LeRoy SG, Natasan JS, Park DJ, Cheah PS, Maus A, Fitzpatrick Z, Hudry E, Pinkham K, Gandhi S, Hyman BT, Mu D, GuhaSarkar D, Stemmer-Rachamimov AO,Sena-Esteves M, Badr CE and Maguire CA. Virus vector-mediated genetic modification of brain tumor stromal cells after intravenous delivery. Journal of Neuro-oncology. 2018; doi: 10.1007/s11060-018-2889-2
  10. Bala U, Leong MPY, Lim CL, Shahar HK, Othman F, Lai MI, Law ZK, Ramli K, Htwe O, Ling KH, Cheah PS. Defects in nerve conduction velocity and different muscle fibre-type specificity contribute to muscle weakness in Ts1Cje Down syndrome mouse model. PLoS One. 2018;13(5):e0197711. doi: 10.1371/journal.pone.0197711
  11. Cheah PS, Usman Bala, Ling KH. Expression of genes involved in the structure and function of skeletal muscles in Ts1Cje mouse model of Down syndrome. Malaysian Journal of Medicine and Health Sciences. 2018; 14(SP1): 12-19.
  12. Jabbarzadeh Kaboli P, Ismail P, Ling KH. Molecular modeling, dynamics simulations, and binding efficiency of berberine derivatives: A new group of RAF inhibitors for cancer treatment. PLoS ONE. 2018; 13(3): e0193941. https://doi.org/10.1371/journal.pone.0193941

2017

  1. WK Yow, R Mahmud, KH Ling & K Thilakavathy. Breast Cancer Associated Mutations Reported Among Malaysian Malay, Chinese and Indian Patients. Progress in Bioscience and Bioengineering, 2017; 1(2): 46-56. DOI: https://doi.org/10.29269/pbb2017.v1i2.19
  2. Kaboli PJ, Bazrafkan M, Ismail P, Ling KH. Molecular modelling of berberine derivatives as inhibitors of human smoothened receptor and hedgehog signalling pathway using a newly developed algorithm on anti-cancer drugs. Recent Patents on Anti-Cancer Drug Discovery, 2017, 12(4): 384-400. doi: 10.2174/1574892812666170929131247
  3. Reza Etemadi M, Ling KH, Zainal Abidin S, Chee HY, Sekawi Z. Gene expression patterns induced at different stages of rhinovirus infection in human alveolar epithelial cells. PLoS One. 2017 May 30;12(5):e0176947. doi: 10.1371/journal.pone.0176947. eCollection 2017. (IF = 3.057)
  4. Manal F, Cheah PS, Ahmad U, M. Nizlan Nasir, Aye AS, Rahim EA, Hussin P, Mahmud R, Fauziah O. Anatomic Variation in Morphometry of Human Coracoid Process among Asian Population. BioMed Research International, 2017 (2017), Article ID 6307019, 10 pages. dos: 10.1155/2017/6307019
  5. S Zainal Abidin, JW Leong, M Mahmoudi, N Nordin, S Abdullah, PS Cheah, KH Ling. In silico prediction and validation of Gfap as miR-3099 target in the mouse brain. Neuroscience Bulletin, 2017 Aug;33(4):373-382. doi: 10.1007/s12264-017-0143-0. Epub 2017 Jun 8.
  6. K.H. Lee, Y.P. Ng, P.S. Cheah, C.K. Lim, M.S. Toh. Molecular characterization of glycation-associated skin ageing: an alternative skin model to study in vitro antiglycation activity of topical cosmeceutical and pharmaceutical formulations. British Journal of Dermatology, 2017, 176: 159-167.
  7. PS Cheah, S Abdullah, H Bahari, DM Chau, O Habib, S Hasan, M Khalid, PL Mok, N Nordin, NJ Tan, A Veerakumarasivam, KH Ling. International Brain Research Organization (IBRO) global neuroscience advocacy programme: Four imperative resolutions to strengthen neuroscience research and development in Malaysia. IBRO Report, 2017, 2, 41-46.

2016

  1. Che Norma MT, Aye AS, Amierul S, Moklas MAM, Cheah PS, Fauziah, O. Unilateral Duplication of Great Saphenous Vein in the Leg – A Cadaveric Case Report. International Journal of Life Sciences Research, 2016, 4 (2): 217-219.
  2. Ahmad U, Aye AS, Cheah PS, Taib CNM, Moklas MAM, Fauziah, O. Discovery of anatomic variant of saphenous nerve- from human cadaver dissection. Journal of Morphological Sciences, 2016, 33: 5-7.
  3. S Azmin, EL Tan, NJ Nik Ruzyanei, Z Hazli, A Mohammed Nawi, ZK Law, R Rabani, WY Nafisah, R Sahathevan, HJ Tan, NFM Pakarul Razy, NA Abdul Murad, KH Ling, MI Norlinah. Impulse control behaviours in a Malaysian Parkinson’s disease population. Neurology Asia, 2016; 21(2): 137-143.
  4. S.W. Mohd-Zin, N.-L. Abdullah, A Abdullah, N.D.E. Greene, P.-S. Cheah, K.-H. Ling, H. Yusof, A.I. Marwan, S.M. Williams, K.T. York, A. Ahmad-Annuar, N.M. Abdul-Aziz. Identification of the genomic mutation in Epha4rb-2J/rb-2J mice. Genome, 2016, 59(7): 439-48. doi: 10.1139/gen-2015-0142.
  5. Leong JW, Abdullah S, Ling KH, Cheah PS. Spatiotemporal expression and molecular characterization of miR-344b and miR-344c in the developing mouse brain. Neural Plasticity. 2016 (2016), Article ID 1951250, 16 pages. http://dx.doi.org/10.1155/2016/1951250
  6. Abubakar, Selvan A, Cheah PS, Abas F, Fakurazi S. Evaluation of wound healing properties of bioactive aqueous fraction from Moringa oleifera Lam on experimentally induced diabetic animal model. Drug Design Development and Therapy. 2016, 10:1715-30. doi: 10.2147/DDDT.S96968.
  7. Ling KH, Brautigan PJ; Moore S; Fraser R; Melody Leong PY, Leong JW, Zainal Abidin S, Lee HC, Cheah PS; Raison JM; Babic M; Young KL; Daish D; Mattiske DM; Mann JR; Adelson DL; Thomas PQ; Hahn CN; Scott HS. In depth analysis of the Sox4 gene locus that consist of sense and natural antisense transcripts. Data in Brief. 2016. 282-290. doi:10.1016/j.dib.2016.01.045
  8. Ling KH, Brautigan PJ; Moore S; Fraser R; Cheah PS; Raison JM; Babic M; Young KL; Daish D; Mattiske DM; Mann JR; Adelson DL; Thomas PQ; Hahn CN; Scott HS. Derivation of an endogenous small RNA from double-stranded Sox4 sense and natural antisense transcripts in the mouse brain. Genomics. 2016, 107(2–3):88–99.
  9. Lee HC, Tan KL, Cheah PS, Ling KH. Potential role of JAK-STAT signalling pathway in the neurogenic-to-gliogenic shift in Down syndrome brain. Neural Plasticity. 2016, Volume 2016, Article ID 7434191, 12 pages. http://dx.doi.org/10.1155/2016/7434191.

2015

  1. MH Borojerdi, M Maqbool, Z Yusoff, S Vidyadaran, KH Ling, E George, R Ramasamy. The Efficiency of Cell Sorting and Harvesting Methods for In vitro Expansion of Human Umbilical Cord Blood derived CD34+ Hematopoietic Stem Cells. Malaysian Journal of Medicine and Health Sciences, 2015; 11(2): 21-28.
  2. Kaboli PJ, Rahmat A, Ismail P, Ling KH. MicroRNA-based therapy and breast cancer: A comprehensive review of novel therapeutic strategies from diagnosis to treatment. Pharmacology Research. 2015 Jul;97:104-21.
  3. Zainal Abidin S, Tan EL, Azmin S, Chan SC, Jaafar A, Alex XL, Noor MH, Murad NAB, Razy NFP, Annuar AA, Lim SY, Cheah PS, Ling KH and Ibrahim NM. DRD and GRIN2B polymorphisms and their association with the development of impulse control behaviour among Malaysian Parkinson’s disease patients. BMC Neurology. 2015 Apr 22;15:59.
  4. Mun-Fun H, Ferdaos N, Hamzah SN, Ridzuan N, Hisham NA, Abdullah S, Ramasamy R, Cheah PS, Thilakavathy K, Yazid MN, Nordin N. Rat full term amniotic fluid harbors highly potent stem cells. Res Vet Sci. 2015 Oct;102:89-99.
  5. Cheah PS, Thomas PQ. SOX3 expression in the glial system of the developing and adult mouse cerebellum. Springerplus. 2015 Aug 7;4:400.
  6. Taher MF, Hussin, P, Nizlan, NM, Cheah PS, Ahmad Umar, Aye AS, Rahim EA, Fauziah O. Easy, Fast and Accessible Dissecting Approach to Coracoid Process of Human Scapula. Res J Pharm Biol. Chem. Sci. 2015, 6(2): 1279-1283.
  7. Kura AM, Saifullah B, Cheah PS, Zobir MH, Azmi N, Fakurazi S. 2015. Acute Oral Toxicity and Biodistribution Study of Zinc Aluminium-Levodopa Nanocomposite. Nanoscale Research Letters. 2015 Mar 1;10:105.

2014

  1. NA Mohamed Hisham, KH Ling and N Nordin. Establishment of conditional transgenic Wnt5A embryonic stem cell line. Regenerative Research, 2014; 3(2): 137-139.
  2. Zainal Abidin S, Abbaspourbabaei M, Ntimi CM, Siew WH, PS Cheah, Rosli R, Nordin N & Ling KH. Mir-3099 is overexpressed in differentiating 46C mouse embryonic stem cells upon neural induction. Malaysian Journal of Medical Sciences, 2014, 21(12): 26-32.
  3. U Bala, KL Tan, KH Ling & PS Cheah. Harvesting the maximum length of sciatic nerve from adult mice: a step-by-step approach. BMC Research Notes, 2014, 7:714. (PMID: 25304607)
  4. KL Tan*, KH Ling*, CA Hewitt*, PS Cheah, K Simpson, L Gordon, MA Pritchard, GK Smyth, T Thomas and HS Scott. Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome. Genomics Data, 2014, DOI: 10.1016/j.gdata.2014.09.009.
  5. Haw RT, Tong CK, Yew A, Lee HC, Phillips JB, Vidyadaran S. A three-dimensional collagen construct to model lipopolysaccharide-induced activation of BV2 microglia. Journal of Neuroinflammation. 2014 Jul 30;11(1):134.
  6. Ling KH*, Hewitt CA*, Tan KL*, Cheah PS, Vidyadaran S, Lai MI, Lee HC, Simpson K, Hyde L, Pritchard MA, Smyth GK, Thomas T and Scott HS. Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks. BMC Genomics, 2014, 15(1): 624. doi:10.1186/1471-2164-15-624
  7. Jabbarzadeh Kaboli P, Rahmat A, Ismail P, Ling KH. Targets and mechanisms of berberine, a natural drug with potential to treat cancer with special focus on breast cancer. European Journal of Pharmacology. 2014 Jun 26. pii: S0014-2999(14)00467-1. doi: 10.1016/j.ejphar.2014.06.025. [Epub ahead of print]
  8. Kura AU, Cheah PS, Hussein MZ, Hassan Z, Tengku Azmi TI, Hussein NF, Fakurazi S. Toxicity evaluation of zinc aluminium levodopa nanocomposite via oral route in repeated dose study. Nanoscale Res Lett. 2014 May 24;9(1):261. doi: 10.1186/1556-276X-9-261. eCollection 2014

2013

  1. Atshan SS, Shamsudin MN, Karunanidhi A, van Belkum A, Lung LT, Sekawi Z, Nathan JJ, Ling KH, Seng JS, Ali AM, Abduljaleel SA, Hamat RA. Quantitative PCR analysis of genes expressed during biofilm development of methicillin resistant Staphylococcus aureus (MRSA). Infection, Genetics and Evolution. 2013 May 10. pii: S1567-1348(13)00187-1. doi: 10.1016/j.meegid.2013.05.002.
  2. Rogers N, Cheah PS, Szarek E, Banerjee K, Schwartz J, Thomas P. Expression of the murine transcription factor SOX3 during embryonic and adult neurogenesis. Gene Expression Patterns. 2013 May 9. pii: S1567-133X(13)00042-2. doi: 10.1016/j.gep.2013.04.004.
  3. Siew WH, Tan KL, Abbaspour Babaei M, Cheah PS and Ling KH. MicroRNAs and intellectual disability (ID) in Down syndrome, X-linked ID and Fragile X syndrome. Frontiers in Cellular Neuroscience. 2013, 7:41. doi: 10.3389/fncel.2013.00041

2012

  1. Gagliardi L, Ling KH, Kok C, Carolan J, Brautigan P, Kenyon R, D’Andrea R, Van der Hoek M, Hahn C, Torpy D, Scott HS. Genome-wide gene expression profiling identifies overlap with malignant adrenocortical tumours and novel mechanisms of inefficient steroidogenesis in familial ACTH-independent macronodular adrenal hyperplasia. Endocrine-Related Cancer. 2012; 19(3):L19-L23. (PMID: 22383426)
  2. Cheah PS, Ramshaw HS, Thomas PQ, Toyo-oka K, Martin S, Coyle P, Guthridge MA, Stomski F, van den Buuse M, Wynshaw-Boris A, Lopez AF and Schwarz QP. Neurodevelopmental defects and neuropsychiatric behaviour arise from 14-3-3ζ deficiency. Molecular Psychiatry, 2012; 17:451-466. doi:10.1038/mp.2011.158. (PMID: 22124272)
  3. Atshan SS, Shamsudin MN, Lung LT, Ling KH, Sekawi Z, Pei CP, Ghaznavi-Rad E. Improved method for the isolation of RNA from bacteria refractory to disruption, including S. aureus producing biofilm. Gene. 2012, 494(2): 219-224. (PMID:22222139)
  4. Lee K, Wong J, Morris M, Rizzoti K, Hughes J, Cheah PS, Felquer F, Liu X, Piltz S, Lovell-Badge R and Thomas PQ. Congenital hydrocephalus and abnormal Subcommissural Organ development in Sox3 transgenic mice. PLOS One. 2012, 7(1): e29041. doi:10.1371/journal.pone.0029041. (PMID: 22291885)

2011

  1. Ling KH, Brautigan PJ, Hahn CN, Daish T, Rayner JR, Cheah PS, Raison JM, Piltz S, Mann JR, Mattiske DM, Thomas PQ, Adelson DL and Scott HS. Deep sequencing analysis of the developing mouse brain reveals a novel microRNA. BMC Genomics, 2011; 12(1): 127. doi:10.1186/1471-2164-12-176. (PMID: 21466694)
  2. Ling KH, Hewitt CA, Beissbarth T, Hyde L, Cheah PS, Smyth GK, Tan SS, Hahn CN, Thomas T, Thomas PQ, Scott HS. Spatiotemporal regulation of multiple overlapping sense and novel natural antisense transcripts at the Nrgn and Camk2n1 gene loci during mouse cerebral corticogenesis. Cerebral Cortex, 2011; 21(3): 683-697. doi: 10.1093/cercor/bhq141. (PMID: 20693275)

2010

  1. Szarek E, Cheah PS, Schwartz J, Thomas P. Molecular genetics of the developing neuroendocrine hypothalamus. Molecular and Cellular Endocrinology, 2010; 323: 115-123. (PMID: 20385202)
  2. Hewitt CA, Ling KH, Merson T, King S, Simpson K, Ritchie M, Pritchard M, Smyth GK, Thomas T, Voss AK, Scott HS. Neurogenesis defects in the adult Ts1Cje mouse model of Down syndrome. PLoS ONE, 2010; 5(7): e11561. doi:10.1371/journal.pone.001156. (PMID: 20661276)
  3. Brown CY, Sadlon T, Gargett T, Melville E, Zhang R, Drabsch Y, Ling M, Strathdee CA, Gonda TJ, Barry SC. Robust, Reversible Gene Knockdown Using a Single Lentiviral Short Hairpin RNA Vector. Human Gene Therapy, 2010; 21(8):1-13. (PMID: 20615123)

2009

  1. Ling KH, Hewitt CA, Beissbarth T, Hyde L, Banerjee K, Cheah PS, Cannon PZ, Hahn CN, Thomas PQ, Smyth GK, Tan SS, Thomas T and Scott HS. Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 sense and antisense transcripts revealed by transcriptome profiling. Genome Biology, 2009; 10(10): R104. (PMID: 19799774)
  2. SF Wai, KH Ling, WY Yee and KL Wan. Sequencing and analysis of a 40kb region from the Toxoplasma gondii genome. Malaysian Journal of Biochemistry and Molecular Biology, 2009; 17(1): 10-15.
  3. Gagliardi L, Hotu C, Casey G, Braund WJ, Ling KH, Dodd T, Manavis J, Devitt PG, Cutfield R, Rudzki Z, Scott HS and Torpy DJ. Familial vasopressin-sensitive ACTH-independent macronodular adrenal hyperplasia (VPs-AIMAH): Clinical studies of three kindreds. Clinical Endrocrinology, 2009; 70(6): 883-891. (PMID: 19018784)

2008

  1. Cao Q, Lu J, Kaur C, Sivakumar V, Li F, Cheah PS, Dheen ST, Ling EA. Expression of Notch-1 receptor and its ligands Jagged-1 and Delta-1 in amoeboid microglia in postnatal rat brain and murine BV-2 cells. Glia, 2008; 56: 1224-1237. (PMID: 18449946)
  2. Cheah PS, Mohidin N, Mohd-Ali B, Myint M, & Azian AL. Histomorphometrical study: corneal response to short-term reverse-geometry orthokeratology lens wear in primate cornea. Cornea, 2008; 27: 461-470. (PMID: 18434851)
  3. Cheah PS, Mohidin N, Mohd-Ali B, Myint M, & Azian AL. The resin-embedded cornea that prepared via rapid processing protocol: a good histomorphometric target for investigational veterinary ophthalmology. Malaysian Journal of Medical Sciences, 2008; 15(3): 49-54.

2007

  1. Cheah PS, Ling KH, Crouse KA and Rosli R. Characterization of the S-benzyldithiocarbazate effects on cell proliferation and oncogene expression in human breast cancer cells. Journal of Medical and Biological Sciences, 2007; 1(2): 1257.
  2. KH Ling, SS Loo, R Rosli, MN Shamsudin, R Mohamed and KL Wan. In silico identification and characterization of a putative phosphatidylinositol 4-phosphate 5-kinase (PIP5K) gene in Eimeria tenella. In Silico Biology, 2007; 7(1): 115-121. (PMID: 17688436)
  3. Ling KH*, Rajandream MA*, Rivailler P*, Ivens A, Yap SJ, Madera AMBN, Mungall K, Billington K, Yee WY, Bankier AT, Carroll F, Durham AM, Peters N, Loo SS, Mat-Isa MN, Novaes J, Quail M, Rosli R, Mariana NS, Sobreira TJP, Tivey A, Wai SF, White S, Wu X, Kerhornou A, Blake D, Mohamed R, Shirley M, Gruber A, Berriman M, Tomley F, Dear P H, Wan KL. Sequencing and analysis of Chromosome 1 of Eimeria tenella reveals a unique segmental organisation. Genome Research, 2007; 17(3): 311-319. (PMID: 17284678)
  4. Cheah PS, Santhana Raj AS, Mohidin N, Mohd-Ali B, Myint M, & Azian AL. Obtain a resin embedded sample in five hours? Believe it! Annals of Microscopy, 2007; 7: 70-79.
  5. Cheah PS, Low KC, Mohidin N, Mohd-Ali B, Myint M, & Azian AL. Ketamine-xylazine/tiletamine-zolazepam: prolonged anesthesia in cynomolgus monkeys. Online Journal of Veterinary Research, 2007; 11: 39-45.

2006 & earlier

  1. Santhana Raj L, Cheah PS, Nor Asiah CP, Teh Hamidah Z, Myint M, Norhani M, Bariah MA & Azian AL. Rapid technique: modified protocols for transmission electron microscope visualization of cornea. Annals of Microscopy, 2006; 6: 36-41.
  2. YH Say*, KH Ling*, G Duraisamy, S Isaac and R Rosli. Angiotensinogen M235T gene variants and its association with essential hypertension and plasma renin activity in Malaysian subject – A case control study. BMC Cardiovascular Disorder, 2005; 5: 7. (PMID: 15811183)
  3. KH Ling, R Rosli, G Duraisamy and MT Mohd Nasir. The prevalence of MTHFR677C>T missense mutation, total homocysteine levels and associated risk factors in Malay subjects. Medical Journal of Malaysia, 2003; 58(2): 243-254. (PMID: 14569745)

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